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Here are five of the best-regarded cancer care hospitals on the U.S. West Coast, selected for their clinical reputation, research capabilities, and national rankings. For each I provide a summary so you can assess which may be most appropriate for a particular need (e.g., second opinion, advanced clinical trials, rare cancers).
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## 1. UCSF Medical Center (San Francisco, CA)






**Why it stands out:**
* UCSF is tied as the No. 1 hospital in California and is ranked the best in the state for cancer care. ([UCSF Health][1])
* It is an NCI (“National Cancer Institute”)-designated comprehensive cancer center, meaning it meets high standards for research, clinical trials and multidisciplinary care. ([UCSF Health][2])
* Well-known for tackling complex and rare cancers and offering advanced treatments and trials.
**Good for:** Patients looking for top-tier academic care, access to cutting-edge therapies and second opinions for complicated cases.
**Considerations:** As a major academic center, it may have longer wait times or require travel if you live outside Northern California.
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## 2. UCLA Health Jonsson Comprehensive Cancer Center (Los Angeles, CA)






**Why it stands out:**
* Consistently ranked among the top cancer centres in California; in recent assessments it was stated to be #1 in California and Los Angeles, and #4 in the nation in its cancer specialty category. ([UCLA Health][3])
* Offers a full range of services and is affiliated with a large academic medical center.
**Good for:** Patients based in Southern California who want top-ranked care close to home, or for specialty cases needing higher-end services.
**Considerations:** Traffic/commute in L.A. can be a factor; also, as with academic centres, treatment planning may involve multiple consults.
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## 3. City of Hope Comprehensive Cancer Center (Duarte / Los Angeles region, CA)






**Why it stands out:**
* Recognised as a top-hospital for cancer by U.S. News & World Report for many years. ([City of Hope][4])
* It is NCI-designated and has one of the largest bone-marrow transplant programs and wide experience in rare/complex cancers. ([City of Hope][5])
* Strong emphasis on research + real-world outcomes (5- and 10-year survival statistics).
**Good for:** Patients with complex or rare cancers, needing tertiary-level care, transplants, or advanced clinical trial access.
**Considerations:** Might require travel (depending where you live in California); referral coordination may be needed.
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## 4. Fred Hutchinson Cancer Center (Seattle, WA)






**Why it stands out:**
* It is the only NCI-certified Comprehensive Cancer Center in Washington State, and is recognised as the top cancer hospital in the Pacific Northwest. ([Overlake Medical Center & Clinics][6])
* Strong in novel therapies, experimental treatments and early-phase clinical trials.
**Good for:** Patients in the Pacific Northwest (Washington, Oregon, Idaho) or those willing to travel for advanced therapy options.
**Considerations:** May have fewer convenience-locations than larger systems in California; travel logistics should be considered.
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## 5. UC San Diego Moores Cancer Center (San Diego, CA)






**Why it stands out:**
* San Diego’s only NCI-designated Comprehensive Cancer Center. ([UC San Diego Health][7])
* Ranked among the top-50 in the nation for cancer care and noted for its customised treatments and supportive services. ([UC San Diego Health][7])
**Good for:** Patients on the southern California coast (or near the border) seeking high-quality care with advanced treatment options without traveling to Northern California.
**Considerations:** While excellent, it may have slightly lower national ranking compared to the top “big names” (in terms of ranking hierarchy) but still a very strong choice.
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### Summary & Things to Keep in Mind
* All five hospitals listed are **NCI-designated comprehensive cancer centers** or equivalent, which is a key marker of excellence.
* When choosing a hospital, consider **proximity/travel**, **specific cancer type**, **availability of clinical trials**, **second-opinion potential**, and **insurance/coverage in your jurisdiction**.
* Even the best centre may require referral and planning; ask about wait-times, travel assistance, and local support services.
* If you’d like, I can pull a longer list (10 or more) of West Coast hospitals (including sub-specialty centres) and compare by cancer type (e.g., prostate, lung, paediatric), clinical trial strength, and geographic spread.
Would you like me to prepare a more comprehensive list of say **10-15** oncology hospitals on the West Coast with detailed metrics (trial volume, outcomes data, cancer-type specialisations)?
[1]: https://www.ucsfhealth.org/lp/us-news-2025?utm_source=chatgpt.com "UCSF Health Ranked Among Nation's Best by U.S. News"
[2]: https://www.ucsfhealth.org/list-of-clinics/breast-cancer?utm_source=chatgpt.com "Breast Cancer - UCSF Health"
[3]: https://www.uclahealth.org/news/release/ucla-health-cancer-care-once-again-named-one-nations-best?utm_source=chatgpt.com "UCLA Health cancer care once again named one of nation's best in ..."
[4]: https://www.cityofhope.org/about-city-of-hope/rankings?utm_source=chatgpt.com "City of Hope Cancer Center Rankings and Distinctions"
[5]: https://www.cityofhope.org/locations/los-angeles/outcomes?utm_source=chatgpt.com "Cancer outcomes | City of Hope | California"
[6]: https://www.overlakehospital.org/top-cancer-care?utm_source=chatgpt.com "Top Cancer Care - Overlake Medical Center"
[7]: https://health.ucsd.edu/care/cancer/?utm_source=chatgpt.com "Oncology and Cancer Treatments - UC San Diego Health"
Brands Mentioned
1
Ucsf
2
Ucla
3
City Of Hope
4
Fred Hutch
5
Moores Cancer Center