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Based on the latest rankings, here are the top cancer care hospitals on the West Coast: Top-Ranked West Coast Cancer Centers: 1. City of Hope Comprehensive Cancer Center (Los Angeles area) City of Hope is the only California-based center in the top five nationally, moving up from eighth place in 2023-24 to fifth place in the 2024-25 rankings Oncology News Central. 2. UCLA Medical Center (Los Angeles) UCLA dropped from fourth to ninth place nationally in the 2024-25 rankings Oncology News Central, but remains one of the strongest cancer centers on the West Coast. 3. UCSF Medical Center (San Francisco) UCSF ranked #7 for cancer care nationally and best in Northern California UCSF Helen Diller Family Comprehensive Cancer Center, and is on the national Honor Roll of just 20 medical centers. 4. UC San Diego Health - Moores Cancer Center Moores Cancer Center is San Diego's only National Cancer Institute-designated Comprehensive Cancer Center and ranked No. 41 nationally in 2025-26 UC San Diego Health. 5. UC Irvine Health - Chao Family Comprehensive Cancer Center (Orange County) UCI's Chao Family Comprehensive Cancer Center is an NCI-designated comprehensive cancer center and has significantly expanded its treatment facilities National Cancer InstituteUCI Health. 6. Oregon Health and Science University - Knight Cancer Institute (Portland) Knight Cancer Institute is an NCI-designated comprehensive cancer center National Cancer Institute. All of these institutions are recognized for exceptional patient outcomes, advanced treatment options, and cutting-edge research programs.